2016 - Vail Scientific Summit

Stem cell therapy is a topic of scientific discussion that many people have heard about – perhaps from a radio commercial for a new clinic - but very few can accurately explain.

A Google search of the term "stem cell clinic" yields more than 1.5 million results. Clinics are sprouting up across the country at an alarming rate, according to a recent study in the journal, Cell Stem Cell. There are now 571 clinics in the United States offering stem cell treatments directly to patients claiming to treat everything from knee injuries and back pain to autism and muscular dystrophy. The claims are frequently unsupported and of questionable benefit.

The physicians, scientists and researchers at the Steadman Philippon Research Institute (SPRI) want to answer those questions and ease some of that uncertainty and confusion about stem cell research. SPRI will be assembling 43 of the top doctors and researchers in the field of regenerative medicine on Aug. 18-20 in Vail, Colo., to participate in the second Vail Scientific Summit. This year’s theme is "Engaging the Greatest Minds in Regenerative Medicine and Science."

"Clearly, people are eager to learn more about how stem cell research might help them overcome or delay the effects of certain illnesses or conditions," says Dan Drawbaugh, CEO of SPRI and The Steadman Clinic.

"SPRI's team of physicians and scientists now know that the process of repairing musculoskeletal tissue through stem cells can be applied to other conditions- cancer, heart disease, aging, and more," continues Drawbaugh.  "Our team is working to identify the conditions that best respond to stem cell therapy. Our research science is changing medicine and restoring and broadening hope for patients. Medicine is entering a new era, and SPRI scientists are on the forefront of these discoveries.

"The impact of their findings is enormous and could produce life-changing outcomes for millions of people worldwide," continues Drawbaugh. "We look forward to sharing SPRI's discoveries and their clinical applications.

"That is why it is so important for us to bring the premiere minds in the field of regenerative medicine and stem cell research together in one place where they can share their findings with each other and then to the world."

The explosion of stem cell clinics around the world has led to some amazing stories, with reports of near-miraculous recoveries and life-changing discoveries being made. The stories sound terrific but are they credible?

Are the benefits described in these stories real? Are people being helped or are some of these clinics taking advantage of patients who desperately seek relief from their pain and discomfort? Are there scientific studies that lend support to the positive reports extolled in these "feel-good" stories?

"We want to help clarify where the current research in stem cells and regenerative and translational medicine is going," said Dr. Johnny Huard, Chief Scientific Officer of SPRI and Distinguished Professor & Vice Chair for Research, Department of Orthopaedic Surgery, University of Texas Health Science Center at Houston. "We have 43 of the very best in the field coming to Vail to share what they have learned. They come from some of the finest research hospitals and universities in North America and represent a wide scope of specialties and study.

"Our goal is not to be overly critical of all the stories out there," continued Huard, who discovered the muscle-derived stem cell, "but to identify the proper treatments and separate some of the myths from what the actual scientific research has discovered."

The participants in the summit will discuss their latest discoveries, share best practices and identify stem cell treatments that – based on science – provide the best benefits to patients suffering from joint injuries, osteoarthritis and more.

If you have questions or want more information about "Vail Scientific Summit," please contact Lynda Sampson, Director of External Relations for The Steadman Clinic and SPRI at: 970-479- 1563 lsampson@sprivail.org.

Engaging the Greatest Minds in Regenerative Medicine and Science
All Times Mountain Daylight Time

Organizing Committee

Dr. Marc Philippon
Steadman Philippon Research Institute
The Steadman Clinic

Dr. Johnny Huard
Steadman Philippon Research Institute
University of Texas Health Science Center at Houston

Dr. Christopher Evans
Mayo Clinic

Dr. William Murphy
Univerisity of Wisconsin

Dr. Samuel Stupp
Northwestern Univerisity

Dr. Walter Lowe
Univeristy of Texas Health Science Center at Houston

 

Thursday, August 18, 2016

Afternoon:  Arrive Vail Mountain Marriott Resort & Spa, 715 West Lionshead Circle, Vail, CO 81657

4:30 – 5:45 pm:  Registration & Cocktail Reception, Location: Vail Mountain Marriott, Mountain View Patio

6:00 – 6:30 pm:  Welcome

• Dr. Marc Philippon, Managing Partner, The Steadman Clinic
  Co‐Chairman Steadman Philippon Research Institute
• Dr. Johnny Huard, Director, Center for Regenerative Sports Medicine
  Chief Scientific Officer, Steadman Philippon Research Institute
  Distinguished Professor & Vice Chair for Research Department of Orthopaedic Surgery, University of Texas Health Science Center at Houston
• Mr. Mike Shannon, Chairman, KSL Partners and Chairman, The Vail Health Services Board
• Mr. Dan Drawbaugh, Chief Executive Officer, The Steadman Clinic and Steadman Philippon Research Institute

6:30 – 7:00 pm:  KEYNOTE ADDRESS: Dr. Johnny Huard, Steadman Philippon Research
Institute and The University of Texas Health Science Center at Houston
“Regenerative & Translational Medicine: A Collaborative Vision”

7:00 pm: Buffet Dinner, Location: Vail Mountain Marriott, Mountain View Patio

Friday, August 19, 2016

7:00 – 7:50 am:  Breakfast Buffet served, Grand Ballroom Foyer

7:55 am:  Introduction by Dr. Johnny Huard, Steadman Philippon Research Institute and The University of Texas Health Science Center at Houston

8:00 – 8:30 am:  KEYNOTE ADDRESS: Dr. Samuel Stupp, Northwestern University
“Musculoskeletal Regeneration with Bioactive Matrices”

SESSION A:  Biologics in Orthopaedic Surgery

CHAIRS:
Dr. Marc Philippon, The Steadman Clinic and Steadman Philippon Research Institute

8:35 – 8:50 am:  Dr. Marc Philippon, The Steadman Clinic & Steadman Philippon Research Institute
“Improving Outcomes and Return to Sport Following Hip Arthroscopy”

9:15 – 9:30 am:  Dr. Peter Millett, The Steadman Clinic
“Clinical applications of biologic therapies in modern shoulder surgery “

9:35 – 9:50 am:  Dr. Matthew Provencher, The Steadman Clinic
“Novel Applications of Osteochrondral Allografts: Where are we in 2016?”

9:55 – 10:15 am:  BREAK, Grand Ballroom Foyer

SESSION B:  Platelet Rich Plasma/BMAC

CHAIRS:
Dr. George Muschler, Cleveland Clinic
Dr. Brian Cole, Rush University

10:20 – 10:35 am:  Dr. George Muschler, Cleveland Clinic
““Musculoskeletal Cell Therapy (i.e. Farming): Finding and Processing the Cells (i.e. Seed Stock) We Need”

10:40 – 10:55 am:  Dr. Brian J. Cole, Rush University
“PRP and Articular Cartilage Disease: Where are we now in 2016?”

11:00 – 11:15 am:  Dr. Thos Evans, The Steadman Clinic
“Current Evidence and Future Prospectives of Bone Marrow Aspirate Concentrate and Platelet‐Rich Plasma Applications in Orthopaedics “

11:20 – 11:35 am:  Dr. Laurie Goodrich, Colorado State University
“Does PRP combined with MSCs improve cartilage healing in an osteochondral defect?”

11:40 – 11:55 am:  Dr. David Frisbie, Colorado State University
“An Off the Shelf PRP or ACS (IRAP) In Vitro Testing”

12:00 – 1:00 pm:  LUNCH BUFFET, Grand Ballroom Foyer

1:05 – 1:35 pm:  KEYNOTE ADDRESS: Dr. Mark Markel, University of Wisconsin
“Musculoskeletal Regeneration Animal Models: Examples at UWMadison”

SESSION C:  Large Animal Models /Biomechanics / BioMotion

CHAIRS:
Dr. Mark Markel, University of Wisconsin
Dr. Wayne McIlwraith, Colorado State University

1:40 – 1:55 pm:  Dr. Wayne McIlwraith, Colorado State University
“Repair of Articular Cartilage Defects with Cartilage Derived Chondroprogenitor Cells in the Horse”

2:00 – 2:15 pm:  Dr. Philip Noble, Baylor College of Medicine
“Simulation of Mechanical Environments in Musculoskeletal Function, Repair and Regeneration”

2:20 – 2:35 pm:  Dr. Scott Tashman, Steadman Philippon Research Institute and The University of Texas Health Science Center at Houston
“Relationships Between Knee Mechanics, Meniscal Changes and Cartilage Degeneration After ACL Reconstruction”

2:40 – 2:55 pm:  Dr. Travis Turnbull, Steadman Philippon Research Institute
“The Role of Robotic Biomechanics in Regenerative Medicine Research”

3:00 – 3:15 pm:  Dr. Bill Rodkey, Steadman Philippon Research Institute
“Microfracture, lessons learned from large animal models”

3:20 – 3:40 pm:  BREAK, Grand Ballroom Foyer

SESSION D:  Stem Cells / Progenitors/ Stem Cell Banking

CHAIRS:
Dr. Bruno Peault, UCLA
Dr. Arnold Caplan, Case Western Reserve University

3:45 – 4:00 pm:  Dr. Arnold Caplan, Case Western Reserve University
“MSCs are not Stem Cells”

4:05 – 4:20 pm:  Dr. Bruno Peault, UCLA
“Perivascular native MSCs for tissue repair and regeneration”

4:25 – 4:40 pm:  Dr. Mikhail Kolonin, University of Texas Health Science Center at Houston
“Adipose Stromal Cells: Pathological Role and Targeting”

4:45 – 5:00 pm:  Dr. Radbod Darabi, University of Texas Health Science Center at Houston
“New Insights in Using Human ES/iPS cells for Skeletal Muscle Regeneration”

5:05 – 5:20 pm:  Dr. Linda McLoon, University of Minnesota
“Extra‐ocular Muscle progenitor cells”

5:25 – 5:40 pm:  Dr. Thomas Payne, University of Colorado
“Processing Stem Cells for Banking and Clinical Trials”

6:30 pm: Cocktails

7:15 pm:  Buffet Dinner, Location: Vail Mountain Marriott

Saturday, August 20, 2016

7:00 – 7:50 am:  BREAKFAST BUFFET served, Grand Ballroom Foyer

7:50 am:  Welcome and good morning by Dr. Johnny Huard

8:00 – 8:30 am:  KEYNOTE ADDRESS: Dr. Christopher Evans, Mayo Clinic
“Gene‐based Approaches to Cartilage Repair”

SESSION E:  Articular Cartilage

CHAIRS:
Dr. Farshid Guilak, Washington University in St. Louis
Dr. Linda Sandell, Washington University in St. Louis

8:35 – 8:50 am:  Dr. Linda Sandell, Washington University in St. Louis
“Treatment of Knee Injury with Anti‐Inflammatory Nano‐particle Technology”

8:55 – 9:10 am:  Dr. Robert Sah, UC San Diego
“Structure and Function of the Native, Degenerate, and Engineered OsteoChondral Interface”

9:15 – 9:30 am:  Dr. Farshid Guilak, Washington University in St. Louis
“Targeted genome engineering to create designer stem cells with autoregulatory properties”

9:35 – 9:50 am:  Dr. Tamara Alliston, University of California, San Francisco
“Mechanoregulation of TGF‐beta Signaling in Joint Crosstalk”

9:55 – 10:10 am:  BREAK, Grand Ballroom Foyer

SESSION F:  Ligament, Tendon, Meniscus & Clinical Outcome

CHAIRS:
Dr. Christopher Harner, The University of Texas Health Science Center at Houston
Dr. Scott Tashman, Steadman Philippon Research Institute and The University of Texas Health Science Center at Houston

10:15 – 10:30 am:  Dr. Martha Murray, Harvard Medical School
"Bridge‐EnhancedTM ACL Repair: A Biologic Approach to ACL Surgery"

10:35 – 10:50 am:  Dr. Christopher Harner, University of Texas Health Science Center at Houston
“Is an Autologous Fibrin Clot Capable of Preserving and Delivering Stem Cells?”

10:55 – 11:10 am:  Dr. James Wang, University of Pittsburgh
“The Role of Tendon Stem Cells in the Development of Degenerative Tendinopathy”

11:15 – 11:30 am:  Dr. Jorge Chahla, Steadman Philippon Research Institute
”The Role of Tendon Stem Cells in the Development of Degenerative Tendinopathy”

11:35 – 11:50 am:  Karen Briggs, Steadman Philippon Research Institute
”Importance of Outcome Based Orthopaedic Research for Regenerative Medicine”

12:00 pm – 12:45 pm:  LUNCH BUFFET, Grand Ballroom Foyer

12:50 – 1:20 pm:  KEYNOTE ADDRESS: Dr. William Murphy, University of Wisconsin
“Leveraging autologous cells and tissues for regenerative medicine”

SESSION G:  Scaffold / Tissue Engineering / Bio‐Printing

CHAIR:
Dr. William Murphy, University of Wisconsin
Dr. Phil Campbell, Carnegie Mellon University

1:25 – 1:40 pm:  Dr. Phil Campbell, Carnegie Mellon University
“Printing Therapeutics”

1:45– 2:00 pm:  Dr. Gang Bao, Rice University
“Engineering Molecular Probes and Machines for Regenerative Medicine”

2:05 – 2:20 pm:  Dr. Yadong Wang, University of Pittsburgh
“Tissue Regeneration without Exogenous Cells”

2:25 – 2:40 pm:  Dr. Cecilia Pascual‐Garrido, University of Colorado
“Novel Scaffolds, Bioprinting in Orthopedics"

2:45 – 3:00 pm:  BREAK, Grand Ballroom Foyer

SESSION H:  Bone Tissue Engineering

CHAIRS:
Dr. Christopher Evans, Mayo Clinic
Dr. Robert Guldberg, Georgia Tech

3:05 – 3:20 pm:  Dr. Robert Guldberg, Georgia Tech
“Bone Regeneration in Compromised Host Environments”

3:25 – 3:40 pm:  Dr. Jeremy Mao, Columbia University
“Tissue regeneration by endogenous stem cells”

3:45 – 4:00 pm:  Dr. Chelsea Bahney, University of California, San Francisco
“Cartilage to bone transdifferentiation: New molecular insights inspire novel therapeutic approaches to bone regeneration”

4:05 – 4:20 pm:  Dr. Karin Payne, University of Colorado
“A Biological Approach to Treating Growth Plate Injuries in the Pediatric Population”

SESSION I:  Muscle and Nerve Regeneration After Injuries and Disease

CHAIRS:
Dr. Johnny Huard, Steadman Philippon Research Institute and University of Texas Health Science Center at Houston
Dr. Susan MacKinnon, Washington University in St. Louis

4:25 – 4:40 pm:  Dr. Susan Mackinnon, Washington University in St. Louis
“Paradigm Shifts in Nerve Surgery: Benchtop to Clinic”

4:45 – 5:00 pm:  Dr. Matthew Wood, Washington University in St. Louis
“From bench to the bedside: re‐evaluating tissue‐engineered nerve constructs”

5:05 – 5:20 pm:  Dr. Yong Li, University of Texas Health Science Center at Houston
“Development of approaches to improve muscle healing after injury”

5:25 – 5:40 pm:  Dr. Thomas Best, Ohio State University
“Exercise as A Means to Mobilize Stem Cells In Muscle Repair”

5:45 – 6:00 pm:  Dr. Vihang Narkar, University of Texas Health Science Center at Houston
“Nuclear Receptors & Co‐regulators: Engineering A Healthy Muscle"

6:05 – 6:15 pm:  CLOSING REMARKS  Dr. Johnny Huard, Steadman Philippon Research Institute and University of Texas Health Science Center at Houston, Dr. Marc Philippon, The Steadman Clinic & Steadman Philippon Research Institute

7:30 pm:  Cocktail Party for Invited Speakers, Lenora at The Sebastian