Steadman Philippon Research Institute (SPRI) conducts clinical trials that are supported philanthropically and through federal awards from the National Institutes of Health (NIH) and Department of Defense (DoD). These trials are an essential element of SPRI’s work, as they accelerate the bench-to-bedside pathway of scientific research. This process, referred to as clinical translation, takes research conducted within SPRI’s laboratories and applies it to patient care.

Clinical trials allow clinicians to understand how therapies, treatments and techniques work in a clinical setting. Through this process, providers practice evidence-based medicine, an important tenet of SPRI and The Steadman Clinic—every treatment and technique is backed by research.

Researcher pipetting samples into a well plate in an SPRI laboratory
Runner crossing a rocky trail outdoors

SPRI’s clinical trials are unique, not only because of the close collaboration with surgeons from The Steadman Clinic, but also because of the institute’s comprehensive approach to science. Where some institutions conduct a regenerative medicine clinical trial strictly within that specialty, SPRI’s regenerative medicine trials are enhanced by the integration of biomechanics, imaging and outcomes. This approach allows researchers and clinicians to use state-of-the-art laboratories to further the explorations of each subject, providing more data to complement the research being conducted.

Some of SPRI’s recent clinical trials include:

  • Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan
  • Fisetin Dosing Equivalence Study
  • The Use of Senolytic Agent to Improve the Benefit of Platelet-Rich Plasma and Losartan for Treatment of Femoroacetabular Impingement and Labral Tear: A Pilot Study
  • The Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis
  • Prospective Evaluation of Platelet-Rich Plasma and Bone Marrow Concentrate Treatment to Accelerate Healing after Anterior Cruciate Ligament Reconstruction
  • SPRI Biomotion: Optimization of Return-to-Duty Protocols after Knee Injury
  • Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial

For more information about SPRI’s clinical trials, please contact clinicaltrials@sprivail.org.