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Johnny Huard
  • Department: Center for Regenerative Sports Medicine

Johnny Huard,

PhD

Director and Chief Scientific Officer

Dr. Johnny Huard is a world-renowned scientist and is currently the Chief Scientific Officer and Director of the Center for Regenerative Sports Medicine at the Steadman Philippon Research Institute (SPRI) in Vail, Colorado. Dr. Huard is also the Distinguished Professor and Vice Chair for Research in the Department of Orthopaedic Surgery at the University of Texas Health Science Center at Houston effective May 1, 2015. In addition, he is the Director of The Brown Foundation Institute of Molecular Medicine Center for Tissue Engineering and Aging Research in Houston, Texas. Prior to his new position at SPRI and UTHealth, for twenty years, Dr. Huard held the Henry J. Mankin Professor and Vice Chair for Musculoskeletal Cellular Therapeutics and the Director of the Stem Cell Research Center in the Department of Orthopaedic Surgery at the University of Pittsburgh. He also held joint appointments in Microbiology and Molecular Genetics, Bioengineering, Pathology and Physical Medicine and Rehabilitation, Pediatrics and the University of Pittsburgh Cancer Institute (UPCI) at the University of Pittsburgh. Dr. Huard was also the Deputy Director of Cellular Therapeutic Research at the McGowan Institute for Regenerative Medicine at the University of Pittsburgh.
 
In his current faculty role, Dr. Huard oversees over twenty five individuals including medical, graduate and undergraduate students, post-doctoral researchers, basic science faculty and staff, clinical research fellows, and technical and administrative staff. He is the Chair of SPRI’s Research Advisory Committee (RAC). He also chairs the Vail Scientific Summit annual meeting each August. This year, there are over 65 speakers from around the world participating in this regenerative medicine program. His research laboratory focuses on the identification, characterization, and clinical application of muscle derived stem cells for the treatment of a myriad of conditions including: 1) Duchene muscular dystrophy (DMD), 2) Critical sized long bone and cranial bone injuries, 3) Acutely injured articular cartilage and articular cartilage damaged by osteoarthritis, 4) Compartment syndrome injured limbs which involve injury to the muscles, nerves, circulatory, lymphatic system vasculature, etc., 5) Infarct injured hearts and cardiomyopathy due to DMD. Some of Dr. Huard’s stem cell research has been used clinically (over 400 patients in Canada and the United States) for the treatment of Urinary incontinence and myocardial infarction. He has authored over 300 manuscripts including peer reviewed articles, review articles, invited papers, and book chapters for various high profile scientific journals including Nature Cell Biology, Nature Biotechnology, Journal of Cell Biology, Journal of Clinical Investigation, Cell Stem Cells , etc. Dr. Huard and his research team have received over 80 awards including the Orthopaedic Society’s prestigious Kappa Delta Award and was also the recipient of the University of Pittsburgh’s Chancellor’s Distinguished Research Award. He has had 757 abstracts accepted for presentation at national and international conferences. Dr. Huard currently serves on multiple editorial boards of scientific journals and reviews numerous scientific papers for a wide variety of scientific journals in his area of expertise and also serves on numerous study review group at the National Institute of Health.
 
 
Current Research Projects:
 
1) NIH RO1 AR06545-01
 
Bone Abnormalities & Healing Defect in Muscular Dystrophy
5/6/14 – 4/30/19
 
2) NIH PO1AG043376  
                          
Cell Autonomous and Non-Autonomous Mechanisms of Stem Defects with Aging
0701/13 – 6/30/18
 
3) DOD W81XWH-14- 2-0003
 
Development of Biological Approaches to Improve Functional Recovery after Compartment Syndrome Injury
01/14/14 – 12/31/19
 
 
Key Publications:
 
1)  Cao B, Zheng B, Jankowski RJ, Kimura S, Ikezawa M, Deasy B, Cummins J, Epperly M, Qu-Petersen Z, Huard J. Muscle stem cells differentiate into hematopoietic lineages but retain myogenic potential. Nat Cell Biol 2003 Jul; 5(7):640-6.
 
2)  Zheng B, Cao B, Crisan M, Sun B, Li G, Logar A, Yap S, Pollett, JB, Drowley L, Cassino T, Gharaibeh B, Deasy B, Huard J, Péault B. Prospective identification of myogenic endothelial cells in human skeletal muscle. Nat Biotech 2007 Sep; 25(9):1025-34. J. Huard corresponding author. PMID: 17767154
 
3)  Crisan M, Park, TS Casteilla, L, Sun B, Zheng B, Yap S, Norotte C, Corselli M, Traas J, Deasy B, Andriolo G, Bühring HJ, Lazzari L, Giacobino JP, Huard J, Péault B. Perivascular origin of mesenchymal stem cells in multiple human tissues. Cell Stem Cell, 2008 Sep 11;3(3):301-13.
 
4)  Lavasani M, Robinson A, Lu A, Song M, Feduska J, Ahani B, Tilstra J, Feldman C, Robbins P, Niedernhofer L, Huard J. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun 2012 Jan; 3:608. PMID: 22215083
 
5)  Lavasani M, Thompson SD, Pollett JB, Usas A, Lu A, Stolz DB, Clark KA, Sun B, Péault B, Huard J. “Human muscle-derived stem/progenitor cells promote functional murine peripheral nerve regeneration.” J Clin Invest. 2014 April 1. 124(4). 1745-56. PMID: 24642464
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