Principal Investigator & Program Director of Genetic and Cellular Engineering
Dr. Ping Guo joined CRSM team in August 2019. Dr. Guo was trained as a post-doctoral fellow in a cancer research laboratory at the University of Pittsburgh Cancer Institute, Pittsburgh, PA. After postdoc training, Ping Guo was working as a research assistant professor for gene therapy of diabetes in Children’s Hospital of Pittsburgh at the University of Pittsburgh. Thereafter Dr. Guo joined Dr. Huard group and moved with Dr. Huard to Houston, TX. Dr. Guo was working as an Assistant Professor in the Department of Orthopaedic Surgery at the UTHealth at Houston. Dr. Guo’s research has been focused on stem cell and gene therapies for the regeneration of cardiac muscle after myocardial infarction, Duchenne Muscular Dystrophy associated cardiomyopathy, diabetes-associated syndromes, and regeneration of articular cartilage. He carried out an NIH funded research for cardiac diseases and he utilized muscle derived stem cells (MDSCs) which Dr. Huard lab found out that MDSCs survive significantly better than skeletal myoblasts due to their high expression of cellular antioxidants, which confers the cells with an increased resistance to stress, and ameliorates left ventricular remodeling for myocardial infarction.
Currently, Dr. Guo has been working in CRSM laboratory in Fort Collins, CO. Dr. Guo involved in the research of stem cell therapy for musculoskeletal injury and diseases. Dr. Guo is an expert on gene editing, gene constructing and viral making, especial in Adeno-Associated viral vectors gene expression. Dr. Guo has been involved in an NIH R21 grant project entitled “Muscle Stem Cells Reprogrammed through Genome Engineering for Autonomously Regulated Anti-Fibrotic Therapy”. This study is to use a novel genome engineering system, the CRISPR-Cas9 gene editing system, to integrate a gene to antagonize TGF-β1-mediated fibrosis and further improve muscle healing after injury.
Dr. Guo assisted with the preparation of several grant applications in Dr. Huard group. Dr. Guo has published more than forty papers including first, co-authored and corresponding authored peer-reviewed articles. Outside of the lab, Dr. Guo loves to fish, hiking and enjoys outdoor activities in Colorado.